Emotion Regulation Lab: Highlighted Projects

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Emotions and our ability to flexibly control them play a key role in mental and physical health. With this as a starting point, our current research examines teen anxiety and risk factors in suicide, the role of cognitive biases in anxiety, stress, and substance-related problems, digital therapeutics, and the impact of technology on well-being and relationships. Fundamental to all these questions is the need to better understand the conditions under which emotions, thoughts, and behavior are aligned to promote our well-being and how interventions or behavioral change can optimize this balance.

Using a multidisciplinary approach (observation, behavior, physiology, brain imaging, eye tracking, novel analytic approaches, and animal-human translational models), our work and that of others in the field highlight the importance of emotional and cognitive flexibility in well-being and disorder, and the need for personalization in the development of novel interventions for stress and anxiety, including the development of digital therapeutics that reduce barriers to access while minimizing perilous aspects of the digital ecosystem.

Anxiety and the Anxiety-Related Threat Bias

Anxiety disorders are the most common mental health problem, one that almost 100 million Americans will struggle with over the course of their lives. A primary goal of our lab is to build understanding of the etiology and effective, affordable prevention and treatment of anxiety and stress-related problems across the lifespan.


Neural signatures of attention to threat. From Dennis-Tiwary et al., 2017



Neural signatures of the anxiety-related threat bias: Assessment and treatment implications. Current treatments are ineffective for over half of people suffering from anxiety. We study alternative treatment approaches that tightly target novel cognitive processes and mechanisms in anxiety. One such mechanism is threat bias, or the mental habit of attending to and preferentially processing threats, real or imagined. In a series of studies, we have examined how the threat bias is expressed on the neural (Dennis & Chen, 2007a, b; Dennis & Chen, 2009; Egan & Dennis-Tiwary, 2018; Dennis-Tiwary, Egan, et al., 2016) and behavioral (Dennis, Chen, & McCandliss, 2008; Egan & Dennis-Tiwary, 2018; O’Toole, DeCicco, Hong, & Dennis, 2011) levels, including how variability in threat bias over time is sensitive to stress and varies with anxiety (Egan & Dennis-Tiwary, 2018) and how changes in neural indices of threat bias predict response to attention training interventions (O’Toole & Dennis, 2012; Dennis-Tiwary, T. A., Denefrio, S., & Gelber, S., 2017).


Capturing the temporal dynamics of threat bias. We further examine how information about threat can both facilitate and disrupt key aspects of cognitive control among anxious individuals (Birk et al., 2011; O’Toole, DeCicco, Hong, & Dennis, 2011) and how neural signatures of threat processing predict anxiety symptoms over time (O’Toole et al., 2013). In addition to theoretical implications for anxiety, findings are relevant for understanding the nature of emotion-cognition integration (Blair & Dennis, 2010; Dennis, O’Toole, & DeCicco, 2012) and directly inform our research on digital mental health and attention bias modification training techniques.

Personal Zen: Gamified Attention Bias Modification Training

Traditional treatment approaches for anxiety, such as selective serotonin reuptake inhibitors and cognitive behavioral therapy (CBT), have demonstrated efficacy, yet many obstacles exist to their wide scale use, including side effects, high cost, and high remission rates (~70% for first-time treatment).


Testing the efficacy of the mobile stress-reduction app, Personal Zen. Computer-based attention bias modification training (ABMT), which is brief, cost-effective, and easy to administer, addresses these barriers. We are among the few labs testing the efficacy of gamified ABMT and have developed an evidence-based smartphone app (iOS) called Personal Zen that harnesses ABMT techniques to reduces stress and anxiety in individuals who play it briefly or regularly.

Personal Zen is currently available on the App Store.

Using Personal Zen for a month reduced the stress hormone cortisol in pregnant women. From Dennis-Tiwary et al., 2017.

We have published several studies (e.g., Dennis-Tiwary, Egan, et al., 2016; Dennis & O’Toole, 2014) documenting anxiety-and stress-reduction effects of Personal Zen in adults along with biobehavioral factors underlying its effects. In a recent randomized clinical trial (Dennis-Tiwary, Denefrio, & Gelber, 2017), using Personal Zen for a month reduced subjective anxiety and stress reactivity in pregnant women, including the stress hormone cortisol. Ongoing studies examine how to boost the beneficial effects of Personal Zen to better personalize treatment.

Technology and Well-being

Despite recent claims that smartphones have psychologically destroyed a generation of Millennials and fueled the epidemic of teen anxiety and suicide in the United States, research on this topic is in its infancy, and much more needs to be known before such causal claims can be made.


Greater preferences for communicating via devices was associated with neural signatures of less effective emotion regulation. From Babkirk et al., 2015.

Your brain on digital technology. In pursuit of this goal, we developed a questionnaire focusing on preferences and beliefs about computer-mediated communication (CMC) use (Babkirk et al., 2015) and have showed that a greater preference for CMC predicts reduced size of and satisfaction with social support, as well as greater neural signatures for negative emotional reactivity and reduced emotion regulation.

More home-based device use predicted less emotional recovery in infants. From Myruski et al., 2017.

Parents, put down your devices. In other research, we developed a novel modification of the classic Still Face paradigm (Myruski et al., 2017). We showed that when mothers used devices in front of their infants and toddlers, children expressed more distress and explored less during play. Moreover, greater habitual use of mobile devices by mothers outside the lab predicted less emotional recovery in infants after an emotional challenge. This is some of the first evidence that confirms many of our intuitions: that, like other for forms of maternal withdrawal and unresponsiveness, mobile-device use can have a negative impact on infant social-emotional functioning and parent-child interactions.

Emotion Regulation

Every day we face emotional challenges – whether it’s a stressful work or school experience, needing to wait for something we want, or a personal loss or threat. Our emotions are necessary tools for adapting to these challenges, but can also get in the way and lead to problems including mental illness. The concept of emotion regulation (ER) helps us understand how emotions help or hinder our ability to lead happy and healthy lives.


Neural signatures for emotion regulation predict adaptive and maladaptive emotion regulation in children. From Babkirk, Rios, & Dennis, 2014.

Clinically-relevant neurocognitive markers for emotion regulation. We have identified neural biomarkers for emotion regulatory competence and vulnerabilities, such as EEG asymmetry and scalp-recorded event-related potentials (ERP). For example, we have used the late positive potential (LPP) to track emotion regulation abilities in children as young as five years of age (Dennis & Hajcak, 2009; Hajcak & Dennis, 2009; DeCicco, Solomon, & Dennis, 2012).

Neural signatures of emotion regulation in adults predicts emotional flexibility and emotion regulatory capacity. From Myruski, Bonanno, & Dennis-Tiwary, 2017.

Such ERPs are developmentally sensitive, and can be used to predict emotion regulation, adjustment, and behavior in children (Babkirk, Rios, & Dennis, 2014; Dennis, Malone, & Chen, 2009; Myruski et al., 2017) and adults (Dennis & Solomon, 2010; Myruski, Bonanno, & Dennis-Tiwary, 2017) and to predict cognitive control capacities (Buss et al., 2011; Brooker et al., 2011).

Cognitive Biases in Substance Dependence

As problems with substance dependence and abuse skyrocket, new evidence-based intervention approaches are needed. We examine the role of novel cognitive factors in problematic drinking, with the goal of developing more targeted and effective treatment approaches.


Poor self-regulation combined with stronger implicit thoughts about alcohol led to more drinking. From Luehring-Jones et al., 2016.

Cognitive biases predict alcohol consumption in problem drinkers. Using methods from behavioral economics, we found (Luehring-Jones et al., 2016) that poor self-regulation combined with stronger implicit and automatic thoughts about alcohol led to more drinking among those at-risk for problem drinking.

Brief ABM reduced alcohol craving in problem drinkers, an effect fully mediated by reductions in implicit cognitive biases towards alcohol. From Luehring-Jones et al., 2017

Mechanisms in attention bias modification for problematic alcohol consumption. Targeting these processes, in another study (Luehring-Jones et al., 2017) we tested an attention bias modification (ABM) technique for reducing problematic alcohol consumption in young adult drinkers with a focus on examining mechanisms underlying efficacy. ABM resulted in significant differences in measures of implicit alcohol-related cognition, alcohol-related AB, and self-reports of alcohol craving. Reductions in craving were fully mediated by ABM-related reductions in alcohol-Stroop interference scores, suggesting a previously undocumented relationship between the two measures. Results document the efficacy of brief ABM to reduce both implicit and explicit processes related to drinking, and highlight the potential intervention-relevance of alcohol-related implicit cognitions in social drinkers.


Emotion Regulation Lab

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All visitors will need to present a photo ID to Visitors Center Associates in order to obtain a pass as well as notify them of their destination – The Emotion Regulation Lab (North Building, Room 636).

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